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mmp12  (R&D Systems)


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    R&D Systems mmp12
    Mmp12, supplied by R&D Systems, used in various techniques. Bioz Stars score: 92/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mmp12/product/R&D Systems
    Average 92 stars, based on 8 article reviews
    mmp12 - by Bioz Stars, 2026-02
    92/100 stars

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    Wild-type (WT) and <t>Mmp12−/−</t> mice were treated i.p. with saline vehicle or 300 mg/kg APAP. (A) Representative photomicrographs (100X) of H&E-stained liver sections from vehicle- and APAP-treated mice at 24 hours. (B) The area of centrilobular necrosis in liver sections of APAP-treated WT and Mmp12−/− mice at 24 hours. (C) Plasma hyaluronic acid levels at 24 hours. (D) Representative photomicrographs showing H&E-stained cross-sections of the left lateral lobes from APAP-treated WT and Mmp12−/− mice at 48 hours. (E) Hepatic photomicrographs (200X) showing PCNA-positive hepatocytes 24 hours after APAP administration. (F) Quantification of PCNA-positive hepatocytes at 24 and 48 hours. N=9–20 mice/group. Data expressed as mean+SEM. Data were analyzed using a Student’s t-test (B, C) or using a two-way ANOVA (F). *Significantly (p<0.05) different from time-matched APAP-treated WT mice.
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    Wild-type (WT) and Mmp12−/− mice were treated i.p. with saline vehicle or 300 mg/kg APAP. (A) Representative photomicrographs (100X) of H&E-stained liver sections from vehicle- and APAP-treated mice at 24 hours. (B) The area of centrilobular necrosis in liver sections of APAP-treated WT and Mmp12−/− mice at 24 hours. (C) Plasma hyaluronic acid levels at 24 hours. (D) Representative photomicrographs showing H&E-stained cross-sections of the left lateral lobes from APAP-treated WT and Mmp12−/− mice at 48 hours. (E) Hepatic photomicrographs (200X) showing PCNA-positive hepatocytes 24 hours after APAP administration. (F) Quantification of PCNA-positive hepatocytes at 24 and 48 hours. N=9–20 mice/group. Data expressed as mean+SEM. Data were analyzed using a Student’s t-test (B, C) or using a two-way ANOVA (F). *Significantly (p<0.05) different from time-matched APAP-treated WT mice.

    Journal: Journal of hepatology

    Article Title: Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12

    doi: 10.1016/j.jhep.2016.12.004

    Figure Lengend Snippet: Wild-type (WT) and Mmp12−/− mice were treated i.p. with saline vehicle or 300 mg/kg APAP. (A) Representative photomicrographs (100X) of H&E-stained liver sections from vehicle- and APAP-treated mice at 24 hours. (B) The area of centrilobular necrosis in liver sections of APAP-treated WT and Mmp12−/− mice at 24 hours. (C) Plasma hyaluronic acid levels at 24 hours. (D) Representative photomicrographs showing H&E-stained cross-sections of the left lateral lobes from APAP-treated WT and Mmp12−/− mice at 48 hours. (E) Hepatic photomicrographs (200X) showing PCNA-positive hepatocytes 24 hours after APAP administration. (F) Quantification of PCNA-positive hepatocytes at 24 and 48 hours. N=9–20 mice/group. Data expressed as mean+SEM. Data were analyzed using a Student’s t-test (B, C) or using a two-way ANOVA (F). *Significantly (p<0.05) different from time-matched APAP-treated WT mice.

    Article Snippet: For studies in which Fibγ 390-396A mice were rescued with exogenous MMP12, wild-type and Fibγ 390-396A mice were treated with APAP, and 6 hours later injected i.p. with 2 μg recombinant mouse MMP12 (rMMP12) (3467-MP, R&D Systems, Minneapolis, MN) or saline vehicle.

    Techniques: Saline, Staining, Clinical Proteomics

    Wild-type (WT) and Fibγ390-396A mice were treated i.p. with 300 mg/kg APAP and 6 hours later injected with PBS vehicle or 2 μg of recombinant mouse MMP12 protein (rMMP12) and evaluated 24 hours after APAP challenge. (A) Representative photomicrographs (100X) of PCNA-positive hepatocytes. (B) Quantification of PCNA-positive hepatocytes. (C) Representative photomicrographs (40X) showing H&E-stained liver sections. (D) The area of centrilobular necrosis in liver sections of APAP-treated mice. N=4 mice/group. Data expressed as mean+SEM. *Significantly (p<0.05) different from WT mice treated with PBS as determined by a one-way ANOVA.

    Journal: Journal of hepatology

    Article Title: Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12

    doi: 10.1016/j.jhep.2016.12.004

    Figure Lengend Snippet: Wild-type (WT) and Fibγ390-396A mice were treated i.p. with 300 mg/kg APAP and 6 hours later injected with PBS vehicle or 2 μg of recombinant mouse MMP12 protein (rMMP12) and evaluated 24 hours after APAP challenge. (A) Representative photomicrographs (100X) of PCNA-positive hepatocytes. (B) Quantification of PCNA-positive hepatocytes. (C) Representative photomicrographs (40X) showing H&E-stained liver sections. (D) The area of centrilobular necrosis in liver sections of APAP-treated mice. N=4 mice/group. Data expressed as mean+SEM. *Significantly (p<0.05) different from WT mice treated with PBS as determined by a one-way ANOVA.

    Article Snippet: For studies in which Fibγ 390-396A mice were rescued with exogenous MMP12, wild-type and Fibγ 390-396A mice were treated with APAP, and 6 hours later injected i.p. with 2 μg recombinant mouse MMP12 (rMMP12) (3467-MP, R&D Systems, Minneapolis, MN) or saline vehicle.

    Techniques: Injection, Recombinant, Staining